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RD TOCRIS一級代理，Z-Guggulsterone供應CAS號39025-23-5

Catalog Number: 3570

Chemical Name: (Z)-Pregna-4,17(20)-diene-3,16-dione

詳細產(chǎn)品信息：

Biological Activity
Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo. More active isomer of guggulsterone (Cat. No. 2013).

Technical Data

• M.Wt:

  312.45

• Formula:

  C21H28O2

• Solubility:

  Soluble to 20 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming

• Purity:

  >98%

• Storage:

  Store at RT

• CAS No:

  39025-23-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.